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Enzymes for Glycobiology - Overview

IBEX produces a family of high purity recombinant glycosaminoglycan (GAG) lyases; Heparinase I, Heparinase II, Heparinase III, Chondroitinase AC and Chondroitinase B.

Competitor enzymes purified from the native strain of Flavobacterium heparinum (also known as Pedobacter heparinus) will almost certainly contain cross-contaminants of other flavo enzymes.

IBEX has developed a proprietary expression system in Flavobacterium heparinum and produces these enzymes at the highest purity.

Using pure enzymes will improve the quality of your results.

Enzyme Substrate

Heparinase I (EC (ratio approx. 3:1). Eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-a-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-a-D-gluc-4-enuronosyl groups at their non-reducing ends Heparinase I cleaves heparin, and to a lesser extent, heparan sulfate. (MSDS Sheet).


Heparinase II (EC unassigned) Heparinase II cleaves heparin and heparan sulfate.



Heparinase III (EC Heparinase III cleaves heparan sulfate exclusively, and does not cleave unfractionated heparin or low molecular weight heparins.


Chondroitinase AC(EC Eliminative degradation of polysaccharides containing 1,4-b-D-hexosaminyl and 1,3-b-D-glucuronosyl linkages to disaccharides containing 4-deoxy-b-D-gluc-4-enuronosyl groups. Chondroitinase AC cleaves chondroitin sulfates A and C.


Chondroitinase B (EC Chondroitinase B cleaves dermatan sulfate.