Cartilage Assays

IBEX assays allow for the study of both the synthesis and degradation of connective tissue components and are powerful tools when used together since they can provide a direct means of investigating joint damage.

C2C Collagen Type II Cleavage Assay (Degradation)

This serum-optimized competitive inhibition assay measures real-time collagen Type II degradation, which may allow physicians/researchers to monitor the progression of Osteoarthritis (OA) and Rheumatoid Arthritis (RA)

C1,2C Collagen Type I and II Cleavage Assay (Degradation)

This serum-optimized assay measures the amount of real-time collagen degradation of both Types I and II, which may allow physicians/researchers to monitor the progression of Osteoarthritis (OA) and Rheumatoid Arthritis (RA).

CPII Procollagen Type II Propeptide Synthesis Assay
(formally known as “ProCollagen II C-Propeptide Assay”)

This serum-optimized assay monitors changes in the rate of synthesis of cartilage components (Type II collagen) indicative of Osteoarthritis (OA) and Rheumatoid Arthritis (RA).

CS846 Aggrecan Chondroitin Sulfate Epitope Synthesis Assay

This serum assay monitors changes in the rate of synthesis of aggrecan, indicative of Osteoarthritis (OA) and Rheumatoid Arthritis (RA).

C2C-HUSA™ Collagen Type II Cleavage Assay (Human Urine Sandwich Assay)

This urine assay measures specific OA pathology-related collagen Type II degradation, which may allow researchers to monitor the progression of collagen II-degradation related arthritis such as Osteoarthritis (OA) and Rheumatoid Arthritis (RA).