Contract Manufacturing – Biosafety Level 1

SEED BANK CREATIONS

  • Wild type & Recombinant Seed Bank Creation
  • High Cell Density Seed Bank Creation

FERMENTATION AND BIOTRANSFORMATION

  • 5L, 40L and 160L Fermentation in batch, fed-batch and continuous modes
  • Psychrophilic, mesophilic, thermophilic, aerobic, anaerobic, and microaerophilic submerged fermentations both in constitutive and inducible modes
  • Microbial and yeast fermentations for the expression of proteins, peptides and enzymes
  • Biotransformation of chemical molecules using microorganisms
  • Flow chemistry using microorganisms or immobilized enzymes

PROTEIN PURIFICATION

  • Ion Exchange chromatography
  • Hydrophobic Interaction chromatography
  • Affinity chromatography
  • Tangential Flow Filtration (Concentration and UF/DF)
  • Dialysis
  • Centrifugation
  • Depth filtration

PROTEIN FORMULATION

  • Stabilizers and excipients selection
  • Liquid formulation
  • Formulations for freeze drying
  • Liquid emulsions

FILLING OF DEVICE COMPONENTS & SMALL CONTAINERS

  • Glass vials
  • Microtubes
  • Polypropylene vials
  • Device disposables

LYOPHILIZATION

  • Reagents in device components
  • Proteins, Enzymes, Peptides
  • Bulk lyophilization

  • IBEX has over 30 years of experience in microbial fermentation and purification.
  • IBEX produces proteins in a variety of hosts.
  • IBEX produces multiple enzymes which are used in medical devices worldwide.