ENZYMES FOR BIOMEDICAL USE

Heparinase I rapidly and specifically neutralizes both unfractionated heparin as well as low molecular weight heparin, allowing baseline hemostasis to be monitored in the presence of these anticoagulants.

Heparinase I is incorporated into disposables from a number of leading diagnostic companies, and is in development for additional diagnostic uses. Heparinase I for diagnostics are produced according to ISO 13485 standards.
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In addition to manufacturing enzymes, IBEX also fills and lyophilizes medical device components for major international diagnostic companies.

These device components are in combination with sophisticated instruments such as the TEG® 5000 Thrombelastograph® Hemostasis Analyzer system which provides comprehensive whole blood hemostasis testing that can help assess bleeding and thrombotic risks, and also monitor antithrombotic therapies.

IBEX produces enzyme reagents for the some of the largest international diagnostic companies.

Our contract services are available for:

• SEED BANK CREATIONS
• FERMENTATION AND BIOTRANSFORMATION
• PROTEIN PURIFICATION
• PROTEIN FORMULATION
• FILLING OF DEVICE COMPONENTS & SMALL CONTAINERS
• LYOPHILIZATION

Reagents are produced according to ISO 13485.
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IBEX has developed a proprietary expression for producing our glycosaminoglycan (GAG) enzymes in Flavobacterium heparinum.  This system allows for producing each enzyme separately from other enzymes thus achieving the highest purity using a well-defined proprietary purification scheme, minimizing the cross contamination of other glycosaminoglycan enzymes which can occur when enzymes are produced from the native strain of Flavobacterium heparinum (Pedobacter heparinus).